Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.
Q Sun, AK Barrett, M Ogishi, H Lyu, H Jiang, H Liu, Y Zhao, GE Rodriguez, P Tao, M Obenaus, KD Householder, Q Tang, TV Lanz, KC Garcia.
Nature, (2026). Link
Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics.
GE Rodriguez*, Y Zhao*, Y Nishiga, F Peprah, J Shen, GC Abhiraman, M Ogishi, C Zhang, J Saco, D Waghray, M Serasanambati, L Torres, BW Simone, L Su, SC Wilson, A Yang, Q Sun, L Picton, RA Saxton, V Bhandarkar, MJ Lee, E Andrews, H Jiang, M Obenaus, M Yen, T Atajanova, CA Blish, S Spranger, EJ Wherry, A Kirane, A Ribas, DH Raulet, A Kalbasi, SK Dougan, M Dougan, J Sage, KC Garcia. *Authors contributed equally
Science, (2026). Link
- Research Highlight by NJ Bernard. Nature Immunology, (2026). Link
- Research Highlight by S Crunkhorn. Nature Reviews Drug Discovery, (2026). Link
Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses. [Preprint]
CB Breuer, M Labrado*, GE Rodriguez*, KC Garcia, NE Reticker-Flynn. *Authors contributed equally
bioRxiv, (2025). Link
Expanding the cytokine receptor alphabet reprograms T cells into diverse states.
Y Zhao, M Ogishi, A Pal, LL Su, P Tao, H Jiang, GE Rodriguez, X Chen, Q Sun, LW Rysavy, S Limsuwannarot, D Waghray, A Kalbasi, KC Garcia.
Nature, (2025). Link
Spontaneous and experimental models of lymph node metastasis.
CB Breuer, Z Xiong, A Wang, GE Rodriguez, GC Abhiraman, KC Garcia, NE Reticker-Flynn.
Nature Protocols, (2025). Link
- News & Views by RJ Gonzalez, C Peng, UH von Adrian. Nature Protocols, (2025). Link
Redirecting immune signaling with cytokine adaptors.
GC Abhiraman, KD Householder, GE Rodriguez, CR Glassman, RA Saxton, CB Breuer, SC Wilson, L Su, M Yen, C Hsu, VG Pillarisetty, NE Reticker-Flynn, KC Garcia.
Nature communications, 16: 2432 (2025). Link
Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman spectroscopy and AI. [Preprint]
K Chang, M Serasanambati, B Ogunlade, H Hsu, J Agolia, A Stiber, J Gu, J Chadokiya, GE Rodriguez, P Singh, S Sharma, A Gonçalves, O Verma, F Safir, N Vu, KC Garcia, D Delitto, A Kirane, JA Dionne.
bioRxiv, (2025). Link
Cytokines 2024: 12th Annual Meeting of the International Cytokine and Interferon Society.
G Rodriguez.
Journal of interferon & cytokine research, (2025). Link
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
NA Caveney*, GE Rodriguez*, C Pollmann,*, T Meyer, MT Borowska, SC Wilson, N Wang, X Xiang, KD Householder, P Tao, LL Su, RA Saxton, J Piehler, KC Garcia. *Authors contributed equally
Molecular cell, 84(10): P1995-2005E7 (2024). Link
Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
JL Silberstein, J Du, KW Chan, JA Frank, II Mathews, YB Kim, J You, Q Lu, J Liu, EA Philips, P Liu, E Rao, D Fernandez, GE Rodriguez, XP Kong, J Wang, JR Cochran.
PNAS, 121(12): e2310866121 (2024). Link
Structural insights into the mechanism of leptin receptor activation.
RA Saxton, NA Caveney, MD Moya-Garzon, KD Householder, GE Rodriguez, KA Burdsall, JZ Long, KC Garcia.
Nature communications, 14(1): 1797 (2023). Link
Biochemical and Functional Evaluation of the Intramolecular Disulfide Bondsin the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin)
LS Cunden, M Brophy, GE Rodriguez, HA Flaxman, EM Nolan.
Biochemistry, 56(43): 5726-5738 (2017). Link